Tuesday, August 28, 2012

Reconnecting. ? Paula's Ponderings

Hello friends.

I know I?ve been out of touch, I?ve been working WAY TOO MUCH.? I?ve not had a second to myself, let alone for anyone else.? So much has happened since May?

First and foremost, I am alive. Just barely.. I?ve been working 80+ hours for months now.? Working on a work project that has consumed my life and not in a good way.? I gained the 10 pounds I lost last year, I am working for a woman who?I can I only describe as grotesque.? Needless to say I?m looking for a new job.

Professionally I?ve exhausted myself ? I?m completely burned out.? Totally spent.? I love the company I work for, I hate the person I?m working with.? I do love the other 95% of the people, but unfortunately to stay in my region I have to work with the person I?m working with. And IMO, life it just too short to work with poisonous people.? So on the hunt I go.

My personal relationships have suffered.? I have not seen most of my friends for months now?? and the ones I have seen it has felt rushed.?I?m disappointed in myself for letting this happen.

Just because I?ve not written doesn?t mean I?ve not kept up with you, my favorite bloggers.? I love you?GG and PG.. you both have kept me going?this year.? Even though I?ve not responded to either of you, I love your posts. Thank you for sharing your life experiences with me. When I?ve needed a connection after long hours at the office, you are the first?two I?ve turned to.?? I?m also interested in Struggling Dad..? Anyone know what happened to him? Did he drop communication due to life?s complexities or can catch up with him on another blog site?

Regarding my main relationship, I?m in one, which is even surprising to me.? ATrain has stuck with me, has taken care of me and the girls ? He is a great dad/father to the cats, and a great partner to me.? He has made more than his fair share of salads, dinners, and plans.? I?ve been an absentee partner for the most part, I?m lucky to have him, that he has been so patient with me. I tear up thinking about his kindness and generosity?towards me over the last 6 months.?

For those of you that have gotten this far, I was able to purchase the house I remodeled and was living in. The ironic thing is that the girls and I now live?with ATrain?so I?am trying to rent my home.? I?m renting it furnished. I did not have a problem renting it in August.? I?ve got 3 people interested for September. I am on the hook to show it to these folks during Labor Day Weekend.

I?m in Boston this week working and visiting with one of my best friends who stopped blogging years ago Unicorns and Rainbows. I do wish she would start blogging again ? she has been doing interesting things and I?m sure her parents and I (along with you) would love to know the latest and greatest.

So, if I had to summarize? my position right now I would say that I?m feeling fat, un-confident, searching for a new path/job/lot in life, have a great?support system with my?boyfriend ATrain, friends C-Licious, Free Bird, Smarty Pants,? and family including Mom and Dad, AbFab, Lil? Darlin, and my Twin. I just need to get off my ass and do something to change where I?m at, the situation I?m in. Stop complaining and DO SOMETHING.

I?ll write more and post pictures of my Santa Cruz weekend soon.

Thanks for reading.

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Source: http://paulasponderings.wordpress.com/2012/08/27/reconnecting/

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Monday, August 27, 2012

Simplifying genetic codes to look back in time

ScienceDaily (Aug. 24, 2012) ? Tokyo Institute of Technology researchers show simpler versions of the universal genetic code can still function in protein synthesis. In addition to understanding early primordial organisms, the research could lead to applications preventing non-natural genetically modified materials from entering the natural world.

Daisuke Kiga and co-workers at the Department of Computational Intelligence and Systems Science at Tokyo Institute of Technology, together with researchers across Japan, have shown that simpler versions of the universal genetic code, created by knocking out certain amino acids, can still function efficiently and accurately in protein synthesis [1].

The researchers conducted experiments altering the genetic code in a test tube. They removed the amino acid tryptophan and discovered that the resulting simplified code could still generate proteins as before.

By knocking out individual amino acids and observing the effects, scientists will be able to understand how early primordial organisms may have functioned and evolved. There will be also numerous applications for simplified genetic strains in laboratory experiments, which could potentially prevent non-natural genetically modified materials from entering the natural world.

Background and future developments

Daisuke Kiga and co-workers of the Department of Computational Intelligence and Systems Science at Tokyo Institute of Technology, together with researchers across Japan, have shown that simpler versions of the universal genetic code -- created by knocking out certain amino acids -- can still function efficiently and accurately in protein synthesis. The researchers conducted cell-free experiments altering the genetic code.

All current life forms on Earth have 20 amino acids in their genetic code. However, scientists believe that this was not always the case, and that organisms evolved from simpler genetic codes with fewer amino acids. Amino acids are linked in accordance with codons -- a 3-letter combination of the four base nucleotides (G, A, T and C) in a genetic code. There are 64 possible codons, and so most amino acids are produced by several different codons, except for tryptophan and methionine, which are generated by just one codon each. Tryptophan is thought to be the most recent amino acid to become part of the universal genetic code.

Kiga and his team took the codon for tryptophan, and reassigned it to code for the amino acid alanine instead. They discovered the resulting simplified code could still generate proteins as before. The researchers also reassigned another codon originally for the amino acid cysteine and replaced it with serine. This simplified code without cysteine was able to synthesize an active enzyme.

By knocking out individual amino acids and observing the effects, scientists will be able to understand how early primordial organisms may have functioned and evolved. There are also numerous applications for simplified genetic codes in laboratory experiments and clinical trials.

Before emergence of the current universal genetic code, primitive organisms that may have used only 19 amino acids could benefit from horizontal gene transfer, where cells transfer genetic material between one another. This is a key method used by bacteria to develop resistance to drugs. An organism with the current universal genetic code for 20 amino acids would have competitive advantages in its ability to synthesize proteins, but could not engage in genetic transfer with the rest of the population. Only when a suitably large gene pool of organisms with 20 amino acids is available could horizontal transfer occur between these life forms and they could then thrive. This implies that organisms with a simpler genetic code could be used as a barrier in laboratory experiments, preventing new genetically modified strains from escaping to the natural world.

[1] A. Kawahara-Kobayashi et al. Simplification of the genetic code: restricted diversity of genetically encoded amino acids. Nucleic Acids Research (2012) As yet unpublished.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/IYGmgWWFLeY/120826170404.htm

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Gen X, Millenials, Baby Boomers: Managing across the ages ...

Photo: ? iStockphoto.com/Brad Killer.

Generational Gaps

By Jennifer Gish/Women@Work

The manager, a Baby Boomer, wants to schedule a meeting where she can sit across the table from her employees and discuss the latest project. Her longtime staff member from the World War II generation is ready to go, looking to share stories about what used to work well for the company. Her Millennial employees, meanwhile, have been bombarding her with e-mails sent while they are out picking up their dry cleaning and running home to feed their dog. They have questions about the project and want instant feedback on the work they?ve done so far.

The meeting is still down the road and everyone is already irritated ? the Boomer because her employees are running personal errands in the middle of the day, and the Millennials because their boss won?t answer their e-mails in a timely manner, i.e. within minutes. And that?s without adding in the Generation Xers who would rather nix the meeting entirely so they can actually work on their piece of the project. Anything else, they think, is micromanagement.

Welcome to the world of work 21st century-style, a world where ? for the first time in modern history ? four generations of workers can make up a company?s profile, according to a 2007 report by AARP (formerly the American Association of Retired Persons). According to the report, by 2014 ? due in part to delayed retirement ? nearly one-third of the U.S. workforce will be age 50 or older, up from 27 percent in 2005. It?s a little like having an extended family of aunts, grandparents and adult children and their offspring all living under one roof.

And just like families, this multi-generational workplace and its inevitable variable work styles can lead to frustration, conflict and poor morale if it?s not handled effectively. At the same time, those same differences ? managed well ? can lead to a stronger organization. The critical ingredient in the recipe for success, the experts say, is in knowing how to manage each generation the right way.

Gayle Healy, a 43-year-old Gen Xer, knows the challenges firsthand. While the gap between her, as director of the Center for Careers and Employment at Hudson Valley Community College, and some of the youngest employees isn?t that wide, she sees the differences all the time.

For Millenials, texting isn?t just for making Friday night plans or keeping in touch with a girlfriend. A Millennial, instead, often prefers to have all of his questions answered via e-mail rather than have a face-to-face conversation with his boss about the latest budget projections.

To adapt, Healy makes it clear what they can and can?t expect. Texting or e-mailing her at 10 p.m. is fine. They just shouldn?t expect an answer until the morning. Keeping the boundaries clear helps manage expectations.

?That?s not always my preferred means of communication. I?m not attached to my cell phone,? she says. ?They know not to expect a response until the next day, and I don?t expect anyone to react to my e-mail instantly.?

A variation on that theme is playing out in offices around the country. Age has become such a hot topic in the world of human resources that some employers are including generational differences in their diversity training, says Joanmarie Dowling, a labor and employment attorney who owns Dowling Law in Albany and who serves as vice president of the board for the Capital Region Human Resource Association.

It?s a complicated dance because the frustration can come from both sides. For Millennials, some tension comes from the fact that work time and personal time aren?t as distinctly separated as they may be for a Boomer, who closes the door on her office at 6 and doesn?t think about ? or at least doesn?t act on ? that stack of performance reviews she has to finish until she unlocks her office the next morning.

Millennials lives are stored in and shared via smartphones. They grew up with Facebook, posting what they had for dinner and who they saw at a party and getting instant feedback on it from friends at all hours.? They?re used to being connected 24/7 via Twitter and text. The phone never shuts off, and so, neither do they. Even when it comes to work.

Theresa Petrone, foundation and public relations administrator for CAP COM Federal Credit Union and president of the Capital Alliance of Young Professionals, says she often hears Millennials talk about how they?re frowned upon for texting or taking a personal call on their cell phones during work time. But because they often answer work e-mails or text with a client on the weekends or off-hours, they feel as if it?s OK to take that time during normal business hours to address personal needs.

?With technology being the way it is, so many of us are hooked into work all the time,? says Petrone, who is 29 and manages three e-mail accounts, Facebook, texts and G-mail chat on her smartphone. ?So we expect that allowance if something comes up with our life in the day. It?s the two worlds meshed together.?

Healy says she and other staff members in her office have discussed whether to embrace the 24-7 plugged-in mentality because that?s the direction of the business world, or whether they should maintain what they consider to be reasonable boundaries between work and home life. She?s opted for her no e-mail answer until the morning rule. Others may decide to jump in. No one way is the right way ? as long as each party is clear on what the other wants.

Being clear on boundaries is particularly important, Dowling says, because the tracking of generational traits isn?t hard science. Personality remains at the heart of most human resource issues and workplace conflicts, and assuming that all Gen Xers are looking for a non-corporate feel at work, while Baby Boomers are slow to change and Millennials are always online can lead to problems.

?Employers really have to be careful about not stereotyping or marginalizing a particular group,? Dowling says, adding that going too far can result in age discrimination. Employers should think before making statements such as ?Sally?s been with us for 20 years, and she?s getting too old for this because we can?t get her to use the latest and greatest computer program,? Dowling says, because employees can be resistant to learning new things at any age.

When generational differences exist, Dowling says mentoring programs can be a good way to bridge the gap and make two generations feel supported and appreciated. Whether it?s an informal or a formal pairing, partnering a longtime Boomer employee with a Millennial can help the younger employee get some needed company wisdom and experience and allows the Boomer to feel like a valued part of the team. It also opens up communication between the two groups and can head off potential miscommunications.

Miguel Berger, president of Better Homes and Gardens Real Estate Tech Valley in Albany and Saratoga counties, says he prefers the ?soft sell? when it comes to mentoring. In his offices, Millennials tend to be more proficient with social media applications such as Facebook, which have become a bigger part of the real estate game. But often, they?re not as comfortable talking to clients face-to-face, and he frequently has to remind his Millennials that ?you cannot purchase a house over text.?

At the same time many Boomer and Gen Xer employees may excel at personal interaction from their years of experience, he says, only to lag behind in social media. He knows, though, that ?nobody wants to be taught anything new, especially when somebody?s been in the business 25-30 years.? So he lets employees informally learn from each other.

?I call it a two-way street,? says Berger, who is 50. ?We do it in a very soft sell.?

Shared experience can feed into some generational traits, says Tom Denham, career counselor and owner of Careers In Transition, LLC in Colonie. Boomers want to feel valued by their employers, while Millennials hunger for mentors, a characteristic acquired during the countless internships they?ve served before arriving at their current jobs. Savvy pairing can help both sides, Denham says.

Millennial Petrone agrees ? as long the mentor realizes her group wants its feedback now, not months down the road. ?We?re so used to having things immediately. We want responses immediately,? she says. ?(Having) six-month reviews and not having constant feedback is frustrating. I think that Boomer generation and the Generation X is more used to work, work, work, and in the end, you kind of review everything. We don?t have attention spans for things. We need to know immediately ? what do you like about it? What do you not like about it??

GENERATIONS AT A GLANCE

World War II aka Greatest Generation (born 1945 and before):

  • Preferred communication format: memos, letters and personal notes.
  • Key traits: experience, enhanced knowledge, dedication, focus, stability, loyalty, emotional maturity and perseverance.
  • Potential issues: may be reluctant to buck the system and uncomfortable with conflict.
  • Really can?t stand: managers who are touchy-feely, indecisive, worry about making unpopular decisions, use profanity, slang or trendy management styles and are disorganized.

Boomers (born 1946-1964):

  • Preferred communication format: phone calls and face-to-face meetings.
  • Key traits: dedication, team perspective, experience and knowledge.
  • Potential issues: may not be ?budget minded,? can be uncomfortable with conflict, reluctant to go against peers and sometimes put more emphasis on the process than the result.
  • Really can?t stand: mangers who aren?t open to input, are bureaucratic, send ?my way or the highway? messages, don?t show interest or try to ?one-up? everyone.

Generation X (1965-1980):

  • Preferred communication format: Voicemails and e-mail.
  • Key traits: adaptability, techno-literacy, independence, creativity and a willingness to buck the system.
  • Potential issues: may be skeptical and distrustful of authority.
  • Really can?t stand: managers who micro-manage, are hypocritical, spend too much time on process and not enough on results, are flashy and bureaucratic and like to schmooze.

Millennials (1980-2000):

  • Preferred communication format: instant messages, blogs, texts and e-mails.
  • Key traits: collective action, optimism, the ability to multi-task and technological savvy.
  • Potential issues: May have a need for supervision and structure and are inexperienced in handling difficult people issues.
  • Really can?t stand: managers who are cynical and sarcastic, treat them as if they are too young to contribute, are threatened by their technological proficiency, are condescending and are inconsistent and disorganized.

? From the AARP?s 2007 report, ?The Changing Landscape of Work.?

TALKING THE TALK
You?ve heard the expression ?it?s not what you said; it?s how you said it.? Here are some suggestions for getting across your ideas effectively to employees in different generations.

World War II aka Greatest Generation: Your experience is respected here. It?s valuable to the rest of us to hear what has and hasn?t worked in the past.

Boomers: You?re important to our success. You?re valued here. Your contribution is unique and important. We need you. I approve of you, and you?re worthy.

Generation X: Do it your way. We?ve got the newest hardware and software. There are few rules here. We?re not very corporate.

Millennials: You?ll be working with bright creative people. We can continue to train and develop you. We will help set you up with a mentor who can help you get where you want to go. (Millennials value mentoring and understand the power of networking more so than any other generations did when they first got out of school, a lot of which can be attributed to the role of social media in their lives.)

? From Tom Denham, career counselor and owner of Careers In Transition LLC in Colonie, based on work by Dennis Gaylor.

Source: http://blog.timesunion.com/womenatwork/gen-x-millenials-baby-boomers-managing-across-the-ages/2024/

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Sunday, August 26, 2012

The Two Sides Of Traffic Building | Traffic Starter Pro

Why do you do online marketing? Although the ultimate desire is to earn sales, the basic idea is to generate traffic, specifically targeted traffic.

The Benefits

This kind of traffic offers many benefits. First it lets you save money. Many Internet marketers think they can get away with spending cash for promotions. They are misled. Sooner they should, such as when creating a webpage. Marketers need to pay web hosting and domain registration.

But because traffic is targeted, you may direct the marketing efforts to prospects who can truly provide returns on investment.

It furthermore means lesser stresses. Achieving success does not happen overnight, and it is correct it is extremely exhausting. But it is more disheartening when your marketing techniques should not have been what you are doing in the first place. You could have avoided this, however, if you have simply generated the right kind of traffic.

The right traffic in addition helps you earn money at a short amount of time. After all, your prospects display the highest interest over your products then are willing to pay.

The Challenges

Building traffic, nevertheless, is not uncomplicated. It is often considered a challenge for online promotion. First, you have to carefully understand your prospects, and this already takes a lot of time. Also, at some point, you should start spending cash. Third, if you are doing this on your own, you may go through a trial-and-error phase.

Thus, many Internet marketers opt to hire traffic generation companies, but this may also carry some issues. Normally problems arise when you pick the wrong team to manage your business. You are not simply wasting resources, but there is a good chance you are dealing with potential scammers.

In the end, building traffic is fundamental; it is mandatory. But you might need some help in building targeted traffic from the best team. Research about their credentials, legitimacy, as well as knowledge. These three can guarantee you can pick the right company.

Buy targeted traffic and unravel how you can surely maximize your online marketing expenses. Targeted Traffic Crew is the ultimate go-to team for traffic services, a formidable way to enhance a business from scratch in a few months. Contact them today for inquiries as well as for more information.

Check these too:

  1. How Do You Define Traffic
  2. Is It Okay To Buy Traffic?
  3. Building Traffic To Your Online Site
  4. Building Site Traffic With Blog Carnivals
  5. Getting Traffic To Your Blog Using Seo Link Building

Source: http://www.trafficstarterpro.com/blog/1733/the-two-sides-of-traffic-building/

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Israeli police arrest suspects in firebomb attack

JERUSALEM (AP) ? Israeli police say they have arrested three Jewish youths from a West Bank settlement as suspects in firebomb attack that wounded six Palestinians in a taxi.

Police spokesman Micky Rosenfeld said Sunday the three suspects were minors, aged 12-13. They will appear in a Jerusalem court to face charges.

The attack 10 days ago targeted a taxi driving in the West Bank. A firebomb struck the vehicle, injuring the six people inside, one seriously. The military suspected Jewish extremists.

Prime Minister Benjamin Netanyahu and other Israeli leaders condemned the firebombing.

Extremist Israeli settlers often attack Palestinians and their property as part of a campaign they call the "price tag," retaliation for either army action against settlers or Palestinian attacks.

Source: http://news.yahoo.com/israeli-police-arrest-suspects-firebomb-attack-153624411.html

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Is it a bird? Is it a plane? ? | livingandstudyingwithME

I?ve found a new cure for afternoon naps ? zooming military aircraft. We had our local airshow yesterday. Surprising it is quite difficult to sleep through a fly by of a Vulcan bomber, not to mention the fighter jets and such. I just powered through. I did looked like a pile of wet noodles by the evening. Even my sister had mercy on me and let me off playing family board games with her. We?indulged?in Being Human ? series 2 and Dexter ? series 3 instead. A wonderful evening of tele.

?

Class of 2002 Reunion

Progress is finally occurring with my school reunion. We got some dates through so we can finally (!) being arranging a date and the specifics. I say ?we? I mean me. I?ve got loads of ideas but whether I can make them happen or not, humm. At least my sister is on board with all of them and has already promised to help sort out some of the paper side. I need lots of stuff printed for display and she is going to help out with ferrying my to a copiers etc.

?

I?ve?realized?organizing?something like this event is actually quite complicated. I mean I knew it would be but we need helpers and I don?t where we are going to get them for free. I can?t be stewarding the parking, on the sign-in desk, on the yearbook desk, on the drinks table and mc-ing at the same time! I?ve only got three spare family members to ?volunteer? to the job as well. Well, we?ll figure something out. My sister suggested that we should just let everyone figure out there own parking and that they were probably capable of pouring their own drinks! True I?m sure, but I?m bound to spend the event?popping?over to check on everything. I?d really like to be able to spend the event circulating and such not being stressed over the organisation side. This is a fanciful dream on my part but I can hope!

?

NanoWriMo

I got my 3,000 words written yesterday so I?m on track to make my target word count if I can write 3,000 today. My characters were very co-operative yesterday for a change. I do wonder whether I will have to cut the chapter I wrote yesterday. I spent 3,000 words describing the arrival of my main character, Victoria?s, family members to a dinner. I wanted to show all the different relationships but it is probably too long. Anyway no editing until the novel is finished! I do seem to be building towards or at least foreshadowing an ending now so that is good news. My characters are arranging themselves to all be in the same place at the same time for the first time in the novel. I?m looking forward to seeing what they have to say to each other.

?

So I?m off to write for a bit, until my sister comes downstairs to interrupt me. Yes, I know I should be doing some Open University work but my brain is a bit crunched today. I can?t seem to get it into gear at the moment. It?surprises?me I can still write but maybe I?ll look back with a clear brain and see that I have to scrap everything I?ve written in this state. Hopefully tomorrow I?ll feel less like my brain is stuck to an ice pole. If I tip my head back it feels like the forehead will rip off, right now it just feels like a brain deep burning sensation.

?

Hours Sleep Today so far : ? 9 hours in 1 sessions :-)
Headache intensity / pain level : 4.5 :-(
Nausea level : 0 :-D
Joint / muscle pain : 2 :-D
Fatigue : 5.5 :-(
Brain Fog : 5.5 :-(

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Source: http://livingandstudyingwithme.wordpress.com/2012/08/25/is-it-a-bird-is-it-a-plane-2/

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Saturday, August 25, 2012

Nanoparticles reboot blood flow in brain

Friday, August 24, 2012

A nanoparticle developed at Rice University and tested in collaboration with Baylor College of Medicine (BCM) may bring great benefits to the emergency treatment of brain-injury victims, even those with mild injuries.

Combined polyethylene glycol-hydrophilic carbon clusters (PEG-HCC), already being tested to enhance cancer treatment, are also adept antioxidants. In animal studies, injections of PEG-HCC during initial treatment after an injury helped restore balance to the brain's vascular system.

The results were reported this month in the American Chemical Society journal ACS Nano.

A PEG-HCC infusion that quickly stabilizes blood flow in the brain would be a significant advance for emergency care workers and battlefield medics, said Rice chemist and co-author James Tour.

"This might be a first line of defense against reactive oxygen species (ROS) that are always overstimulated during a medical trauma, whether that be to an accident victim or an injured soldier," said Tour, Rice's T.T. and W.F. Chao Chair in Chemistry as well as a professor of mechanical engineering and materials science and of computer science. "They're certainly exacerbated when there's trauma with massive blood loss."

In a traumatic brain injury, cells release an excessive amount of an ROS known as superoxide (SO) into the blood. Superoxides are toxic free radicals, molecules with one unpaired electron, that the immune system normally uses to kill invading microorganisms. Healthy organisms balance SO with superoxide dismutase (SOD), an enzyme that neutralizes it. But even mild brain trauma can release superoxides at levels that overwhelm the brain's natural defenses.

"Superoxide is the most deleterious of the reactive oxygen species, as it's the progenitor of many of the others," Tour said. "If you don't deal with SO, it forms peroxynitrite and hydrogen peroxide. SO is the upstream precursor to many of the downstream problems."

SO affects the autoregulatory mechanism that manages the sensitive circulation system in the brain. Normally, vessels dilate when blood pressure is low and constrict when high to maintain an equilibrium, but a lack of regulation can lead to brain damage beyond what may have been caused by the initial trauma.

"There are many facets of brain injury that ultimately determine how much damage there will be," said Thomas Kent, the paper's co-author, a BCM professor of neurology and chief of neurology at the Michael E. DeBakey Veterans Affairs Medical Center in Houston. "One is the initial injury, and that's pretty much done in minutes. But a number of things that happen later often make things worse, and that's when we can intervene."

Kent cited as an example the second burst of free radicals that can occur after post-injury resuscitation. "That's what we can treat: the further injury that happens because of the necessity of restoring somebody's blood pressure, which provides oxygen that leads to more damaging free radicals."

In tests, the researchers found PEG-HCC nanoparticles immediately and completely quenched superoxide activity and allowed the autoregulatory system to quickly regain its balance. Tour said ROS molecules readily combine with PEG-HCCs, generating "an innocuous carbon double bond, so it's really radical annihilation. There's no such mechanism in biology." While an SOD enzyme can alter only one superoxide molecule at a time, a single PEG-HCC about the size of a large protein at 2-3 nanometers wide and 30-40 nanometers long can quench hundreds or thousands. "This is an occasion where a nano-sized package is doing something that no small drug or protein could do, underscoring the efficacy of active nano-based drugs."

"This is the most remarkably effective thing I've ever seen," Kent said. "Literally within minutes of injecting it, the cerebral blood flow is back to normal, and we can keep it there with just a simple second injection. In the end, we've normalized the free radicals while preserving nitric oxide (which is essential to autoregulation). These particles showed the antioxidant mechanism we had previously identified as predictive of effectiveness."

The first clues to PEG-HCC's antioxidant powers came during nanoparticle toxicity studies with the MD Anderson Cancer Center. "We noticed they lowered alkaline phosphatase in the liver," Tour said. "One of our Baylor colleagues saw this and said, 'Hey, this looks like it's actually causing the liver cells to live longer than normal.'

"Oxidative destruction of liver cells is normal, so that got us to thinking these might be really good radical scavengers," Tour said.

Kent said the nanoparticles as tested showed no signs of toxicity, but any remaining concerns should be answered by further tests. The researchers found the half-life of PEG-HCCs in the blood ? the amount of time it takes for half the particles to leave the body ? to be between two and three hours. Tests with different cell types in vitro showed no toxicity, he said.

The research has implications for stroke victims and organ transplant patients as well, Tour said.

Next, the team hopes to have another lab replicate its positive results. "We've repeated it now three times, and we got the same results, so we're sure this works in our hands," Kent said.

###

Rice University: http://media.rice.edu

Thanks to Rice University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/122918/Nanoparticles_reboot_blood_flow_in_brain

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